PROREACT P BIOREACTORS ON LABORATORY AND PILOT SCALE

PLANT DESCRIPTION

PROREACT P laboratory and pilot fermenters are designed for processes with very high sterile requirements. Standard sizes from 10 – 1.500 L are available. They are used for research and development as well as preliminary stages within a production fermenter cascade of increasing size (see PROREACT P Production Bioreactors and PROREACT “seed train”).

For this reason the plants are designed similar to the industrial plants themselves, so that the same philosophy can be found in the area of process control, automation structure and maintenance as in production processes.

The PROREACT P fermenters for research purposes are configured much more flexible

This concerns the interchangeability of different agitators, different process strategies and the connection of various additional sensors or modules for upstream and downstream processing. As special applications, smaller fermentation units can also be integrated into a plant.

Via a number of open communication interfaces, the plants can be connected to data evaluation programs, laboratory management programs or even complex SCADA systems.

A basic unit consists of the following plant components:

• Pressure vessel -1 to 6 bar (optionally higher pressures) with double jacket made of stainless steel 1.4404/1.4435
• Surfaces in contact with product with Ra ≤ 0.8 μm (optional Ra ≤ 0.4 μm with electropolishing)
• Mixing and gassing unit with various selectable agitators
• Thermosiphon unit for mechanical seals
• Piping and fittings in DIN 11864
• Automatic diaphragm valves in the product area
• Integrated peristaltic pumps for substrates, adjusting agents and antifoam agents
• Compact frame to hold all pipes and aggregates
• Sterile filter units for supply and exhaust air
• Air volume control
• Sterilizable sampling valve
• SIP connection with condensate lines
• CIP connection with valve technology for automatic cleaning
• Bioreactor sensors and sensors for peripheral units
• Central control unit with SIEMENS SPS and touch panel

Individual PROREACT laboratory/pilot fermenters can be combined with the production fermenters for a production line over several cultivation stages (e.g. 20 L, 200 L, 2,000 L, 20,000 L) to form a complete stage structure.

Frings considers the customer-specific requirements and qualification standards

It is also possible to adapt the entire architecture to automation. The SIEMENS industrial control systems used as a platform for this purpose allow for a variety of possibilities, which we would be happy to use for you in a demand-oriented manner.

For the development and production of biopharmaceutical or medical fermentation products, the systems are also supplied with the corresponding GMP documentation. For these plants of the PROREACT G series, special attention is paid to customer-specific qualification standards.

The document management is closely based on the customer’s own specifications and of course the systems are also realized with the customer’s respective components and design specifications.

The same applies to all PROREACT products. If you, as a customer, have special factory standards or construction specifications, we are happy to integrate these requirements already in our basic engineering and build you your customized system.

DIFFERENT DESIGN STANDARDS OF FRINGS BIOREACTORS:

• PROREACT P: Bioreactors for sterile technical processes in biotechnology
• PROREACT B: Bioreactors for hygienic processes especially in brewery, baker’s yeast and beverage applications
• PROREACT G: Bioreactors with equipment and documentation according to GMP pharmaceutical standards
• PROREACT C: Bioreactors without sterile or hygienic design according to chemical standards (for auto sterile processes)