PROREACT P laboratory and pilot fermenters are designed for processes with very high sterile requirements. Standard sizes from 10 – 1.500 L are available. They are used for research and development as well as preliminary stages within a production fermenter cascade of increasing size (see PROREACT P Production Bioreactors and PROREACT « seed train »).
For this reason the plants are designed similar to the industrial plants themselves, so that the same philosophy can be found in the area of process control, automation structure and maintenance as in production processes.
This concerns the interchangeability of different agitators, different process strategies and the connection of various additional sensors or modules for upstream and downstream processing. As special applications, smaller fermentation units can also be integrated into a plant.
Via a number of open communication interfaces, the plants can be connected to data evaluation programs, laboratory management programs or even complex SCADA systems.
A basic unit consists of the following plant components:
Individual PROREACT laboratory/pilot fermenters can be combined with the production fermenters for a production line over several cultivation stages (e.g. 20 L, 200 L, 2,000 L, 20,000 L) to form a complete stage structure.
It is also possible to adapt the entire architecture to automation. The SIEMENS industrial control systems used as a platform for this purpose allow for a variety of possibilities, which we would be happy to use for you in a demand-oriented manner.
For the development and production of biopharmaceutical or medical fermentation products, the systems are also supplied with the corresponding GMP documentation. For these plants of the PROREACT G series, special attention is paid to customer-specific qualification standards.
The document management is closely based on the customer’s own specifications and of course the systems are also realized with the customer’s respective components and design specifications.
The same applies to all PROREACT products. If you, as a customer, have special factory standards or construction specifications, we are happy to integrate these requirements already in our basic engineering and build you your customized system.
The PROREACT P basic units can be equipped with a variety of different standard modules, so that the handling of the plants can be simplified and the range of possible bioprocessing techniques can be extended significantly.
To minimize or completely avoid the use of antifoam agents, the installation of the optionally available FOAMEX foam centrifuge is recommended. The ALCOSENS measuring probe allows extended process documentation for fermentations with alcohol as substrate or metabolite. In addition, control strategies for methylotrophic yeasts are easily possible with it.
In addition to the configuration of bioreactors from standard construction kits and modules, Frings can also implement completely customized solutions.
Especially novel processes from development often require bioreactor designs that deviate from the usual standards.
One of Frings’ core competences is to realize designs and bioreactor equipment adapted and optimized to the bioprocess.
For this purpose we use appropriate design tools and are also able to carry out experimental investigations in the company’s own laboratory and pilot plant in order to find the ideal technical solution.
In the past we have already realized various projects with customers and are particularly qualified in the segments: