PROREACT P PRODUCTION BIOREACTORS

Process-specific CIP and SIP stainless steel bioreactors for the industrial production of bioproducts under strictly monoseptic conditions

PROREACT 60 P as production reactor with PROREACT 25 P as pre-culture fermenter

PRODUCT DESCRIPTION

PROREACT P production bioreactors have a more sophisticated sterile design than the PROREACT B series. These plants meet the highest demands on cleanability and sterilizability, component and material properties and fermenter equipment.

In most cases we adapt our systems to the special requirements of the process and of course to the factory standard of our customers. Further aspects such as installation planning, routing or required geometric specifications are of course taken into account.

PLANT COMPONENTS AND CHARACTERISTICS:

  • Pressure vessel with double jacket -1 – 3 bar (optionally higher pressures) made of stainless steel 1.4404/1.4435
  • Surfaces in contact with product with Ra ≤ 0.8 μm (optional ≤ 0.4 μm and electropolishing)
  • Mixing and gassing unit with various selectable agitators
  • Thermosiphon unit for mechanical seals
  • Double jacket with several cooling/heating zones and optional gas-tight welded insulation
  • Optional internal or external heat exchangers in contact with the product
  • Piping and fittings according to DIN 10357 and DIN 11864 for substrates and products
  • Use of diaphragm valves in the product area
  • CIP and SIP connection for cleaning and sterilization
  • Compact skids for holding all pipes and aggregates and for fast installation on site
  • Sterile filter units for supply and exhaust air
  • Condensate system
  • Extended sensor technology
  • Central control unit with SIEMENS SPS and touch panel

Tests and documentation for smooth operation

The plant components are prefabricated as « package units / skids » in the factory in Rheinbach (Germany). A factory acceptance test (FAT) is conducted in your presence.

On customer request, all engineering, manufacturing, programming and installation processes are also qualified according to GMP (Good Manufacturing Practice) specifications. The GMP-documented plants are then subject to the designation PROREACT G.

PROJECT DEVELOPMENT

In the case of production plants, pre- or basic engineering is often carried out in advance of the contract award in order to evaluate the economic efficiency with regard to investment and operating costs as well as to determine the exact user requirement specifications or a tender.

We can take over the corresponding pre-planning in our project department for you, the customer, and thus minimize the interfaces.

This also applies to the interfaces for upstream and downstream processing. Here we are able to plan and implement even large, complex process units with our contracting partners.

DIFFERENT DESIGN STANDARDS OF FRINGS BIOREACTORS:

  • strong>PROREACT P: Bioreactors for sterile technical processes in biotechnology
  • strong>PROREACT B: Bioreactors for hygienic processes especially in brewery, baker’s yeast and beverage applications
  • strong>PROREACT G: Bioreactors with equipment and documentation according to GMP pharmaceutical standards
  • strong>PROREACT C: Bioreactors without sterile or hygienic design according to chemical standards (for auto sterile processes)
CONTACT Biotech-Team

OBTENEZ DES CONSEILS MAINTENANT:

Tel.: +49 (0)22 26 89 29 – 400
biotech@frings.com

NOUS NOUS RÉJOUISSONS DE VOS QUESTIONS ET TÂCHES. CONTACTEZ-NOUS DÈS MAINTENANT !

HEINRICH FRINGS GMBH & CO. KG

Boschstraße 32 53359 Rheinbach
Tel.: +49 (0)22 26 89 29 – 400 Fax: +49 (0)22 26 89 29 – 401